What Is Matrixyl Synthe'6? Benefits & How It Works

What is Matrixyl Synthe'6?

Matrixyl Synthe'6 is a peptide ingredient used in anti-aging skincare. Its INCI (International Nomenclature of Cosmetic Ingredients) name is Palmitoyl Tripeptide-38. It was developed by the ingredient manufacturer Sederma and is included in INTOIT's 6X Complex Face Serum as part of a multi-peptide formula. Peptides like this one are small chains of amino acids that act as signals, telling skin cells to carry out specific repair and rebuilding tasks.

Source

Found in	Palmitoyl Tripeptide-38 (INCI name)
Origin	Synthetic peptide, developed by Sederma
Also known as	Matrixyl Synthe'6, Matrixyl Synthe-6

Top features and benefits

Supports collagen production	Helps smooth the look of fine lines and wrinkles	Supports skin firmness and elasticity
Supports hyaluronic acid production	Targets the dermal-epidermal junction	Generally well tolerated, including on sensitive skin
Fragrance-free formulations available	Can be used morning and night	Pairs well with hyaluronic acid

How Does It Work?

Matrixyl Synthe'6 works by sending a signal to skin cells that mimics tiny pieces of the skin's own support structure. This tells the cells to ramp up production of six key building blocks that keep skin firm and smooth, including several types of collagen, hyaluronic acid, and other structural proteins. In simple terms, it prompts skin to rebuild its own scaffolding from the inside, rather than just sitting on the surface.

As we age, this scaffolding naturally breaks down faster than the body can replace it, which is what shows up as fine lines, sagging, and a tired-looking complexion. By nudging skin to produce more of several building blocks at once instead of just one, Matrixyl Synthe'6 is designed to help with firmness and smoothness from within the skin, not just on top of it.

In studies, people who used a 2 percent formula twice a day saw visibly smoother forehead lines and crow's feet after about two months, with results continuing to improve the longer they kept using it.

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Frequently Asked Questions

Is Matrixyl Synthe'6 safe for sensitive skin?

Matrixyl Synthe'6 is generally considered non-irritating and is commonly used in fragrance-free formulations suited to sensitive skin. As with any new active ingredient, it is a good idea to patch test first.

How long does it take to see results?

Published studies typically show visible smoothing of forehead lines and crow's feet after around two months of consistent, twice-daily use, with results continuing to improve over time.

Can Matrixyl Synthe'6 be used with other actives?

Yes. It is commonly paired with hydrating ingredients like hyaluronic acid. As with any new active, it is best to introduce it gradually alongside your existing routine.

What is the INCI name for Matrixyl Synthe'6?

Its INCI name is Palmitoyl Tripeptide-38. Matrixyl Synthe'6 is the trademarked name used by its manufacturer, Sederma.

Why is there limited independent research on peptides like Matrixyl Synthe'6?

Most cosmetic peptides are patented, which means the company holding the patent is usually the only party with a strong financial reason to fund clinical studies on that specific peptide. This is a known pattern across the peptide category, not something specific to Matrixyl Synthe'6, and it is why the evidence for many newer peptides tends to come mainly from manufacturer-funded research.